Complex Orthodontic Treatment Using a New Protocol for the Invisalign Appliance

The system was introduced at an orthodontic meeting in 1999 and first described in a peer-reviewed publication in 2000. Controversy remains over whether the system is appropriate for moderate-to-difficult cases.

Early longitudinal clinical trials demonstrated successful use of Invisalign for tipping movements, incisor rotations, and closure of naturally occurring spaces. The system was less...